Patient- and cell line derived xenografts
- More than 600 well characterized PDX models of solid and hematological tumors
- Availability of molecular data, drug response data and clinical data sets
- CDX models covering all major tumor types
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Immuno-oncology models
- Broad collection of humanized and syngeneic models
- In-house humanization with various immune cell populations
- Supporting in vitro cell assays with the Incucyte® Live-Cell Analysis System
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Orthotopic models
- Monitoring of tumor progression by bioluminescence imaging (BLI), ultra sound and flow cytometry
- Orthotopic models to study metastasis using established protocols
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Radiation Therapy
- Administration of radiation using the Multirad X-Ray irradiation system to simulate clinically relevant irradiation schedules
- Permission to conduct in vivo studies with a broad variety of radioisotopes
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Histopathology services
- Supervision of necropsy procedure by a board-certified pathologist
- Standard hematoxylin and eosin (H&E) histology including evaluation
- Immunohistochemistry (IHC) on both frozen and paraffin sections
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Bioinformatics and biostatistics services
- Gene expression profiling of selected genes or gene signatures
- HLA matching for immuno-oncology studies
- Calculation of optimal sample sizes to achieve sufficient statistical power
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Pharmacokinetic & toxicology studies
- Broad variety of possible PK study designs for determining a suitable dosing schedule and route of administration
- Dose escalation studies for Maximum-Tolerated Dose (MTD) determination
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Cell based in vitro assays & molecular analyses
- In vitro screening in 2D and 3D in a drug concentration and time dependent manner
- Automated live cell imaging with the IncuCyte® system to evaluate drug action
- Molecular analyses to identify and to verify target expression on RNA and protein level
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